Eur Rev Med Pharmacol Sci.2012 Dec;16(15):2051-6.

Regulationnetworkanalysis in the esophageal squamous cell carcinoma.

Xiang J¹,Zang W,Che J,Chen K,Hang J.

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Abstract

BACKGROUND:

The incidence of esophageal squamous cell carcinoma (ESCC) has high regional selectivity. The molecular mechanisms of ESCC are complex and involve multiple oncogenes, tumor suppressor genes, receptor tyrosine kinases, cytoplasmic enzymes, and tumor interstitial elements.

AIM:

Here we used bioinformatics to obtain some important genes and pathways involved in ESCC.

MATERIALS AND METHODS:

In this article, we did Affymetrix microarray data collection from three big databases, and then selected all the differentially expressed genes (DEGs) according to some principles. On this basis, we carried outregulationnetworkanalysis and pathway enrichment analysis, obtaining ESCC relatedregulationnetworkanalysis, after which we selected significant pathways onregulationnetworkand established TF-pathwayregulationnetwork.

RESULTS:

In the transcription factors (TFs)regulationnetworkwe found SP1, E2F1, USF2 and SP3 form a localnetworkwhich suggested that these TFs might play a more important role in ESCC. Some key pathways were also identified, such as P53 signaling pathway, melanoma and prostate cancer pathways.

CONCLUSIONS:

The identification of crucial molecular pathways involved in ESCC would ultimately improve therapeutic effects and facilitate the development of new treatment strategies.