陈伟呈

专业擅长

先天性心脏病（房间隔缺损，室间隔缺损，卵圆孔未闭，动脉导管未闭，法洛氏四联症），小儿纵隔肿瘤，小儿肺部疾病（囊性变，隔离肺，肺大疱），小儿胸廓畸形（漏斗胸，鸡胸），小儿气道疾病（气道狭窄），纤毛不动症/原发性纤毛功能障碍

个人简介

先天性心脏病（房间隔缺损，室间隔缺损，卵圆孔未闭，动脉导管未闭，法洛氏四联症），小儿纵隔肿瘤，小儿肺部疾病（囊性变，隔离肺，肺大疱），小儿胸廓畸形（漏斗胸，鸡胸），小儿气道疾病（气道狭窄），小儿外科常见疾病（隐睾，斜疝，脐疝，鞘膜积液），纤毛不动症/原发性纤毛功能障碍

社会任职

上海市医学会心脏大血管外科青年委员

获奖荣誉

复旦大学优秀学生 复旦大学 2012.11上海市优秀毕业生 上海市教委 2013.5优秀论文奖（先心病患儿合并心外先天性畸形的回顾性研究） 中华医学会小儿外科分会 2017.09病例分享优胜奖 复旦大学附属儿科医院 2017.12爱惜康菁英大赛第四届以爱为名心外青年医师手术技能大赛区域赛（杭州站）室缺组，二等奖 强生公司 2019.05上海市医学会青年人才培养计划铸才工程-菁英计划“爱由心生”心外青年医师PK赛（室缺修补术组）三等奖 上海医学会 2019.07最佳援滇医务工作者 绿春县县人民政府扶贫开发办公室 绿春县卫生健康局 2020.11优秀员工奖 复旦大学附属儿科医院心血管中心 2020.12

科研成果

1.Weicheng Chen#, Yuan Zhang#, Sunhu Yang#, Zhiwen Shi,Weijia Zeng,Zhouping Lu, Xiangyu Zhou*. BiAllelic Mutations in NUP205 and NUP210 Are Associated With Abnormal Cardiac Left-Right Patterning. Circulation: Genomic and Precision Medicine, 2019, 12(7):329-332. 2.Sida Liu#, Weicheng Chen#, Yongkun Zhan, Shuolin Li, Xiaojing Ma, Duan Ma, Wei Sheng*, Guoying Huang*.DNAH11 variants and its association with congenital heart disease and heterotaxy syndrome.Scientific Reports, 2019,9(1):6683.3.Weicheng Chen#, Zhuoyao Guo#, Liling Qian*, Libo Wang*. Comorbidities in situs inversus totalis: A hospital-based study. Birth Defects Res, 2020, 112(5):418-426.4.Zhuoyao Guo#, Weicheng Chen#, Jianfeng Huang, Libo Wang*, Liling Qian*. Clinical and genetic analysis of patients with primary ciliary dyskinesia caused by novel DNAAF3 mutations. Journal of Human Genetics, 2019, 64(8):711-719.5.Weicheng Chen#，Xiaodi Li#，Liqun Sun，Wei Sheng* and Guoying Huang*. A rare mosaic 22q11.2 microdeletion identified in a Chinese family with recurrent fetal conotruncal defects. Mol Genet Genomic Med. 2019, 7(8):e847.6.Weicheng Chen#, Sida Liu#, Huifang Hu#, Gang Chen, Shaicheng Zhu, Bing Jia, Wei Sheng, and Guoying Huang*. Novel homozygous ataxia-telangiectasia (A-T) mutated gene mutation identified in a Chinese pedigree with A-T. Mol Med Rep.2019, 20(2):1655-1662.7.Chen Wei-Cheng#, Zhang Ying., Ma Duan., Ma Xiao-Jing., Shou Wei-Nian., Huang Guo-Ying*. Bmp2 regulates the interaction between EPDCs and myocytes in cardiac OFT. Med Hypotheses, 2012, 79(2):174-177. 8.Yongkun Zhan#, Weicheng Chen#, Zhiyu Feng, Chaozhong Tan, Mengru Li, Yangliu Song, Zhengshan Zhao, Wei Sheng*, Guoying Huang*.A novel de novo PDE4D gene mutation identified in a Chinese patient with acrodysostosis. Genesis. 2019, 57(11-12):e23336. 9.Guo Zhuoyao#, Chen Weicheng#, Wang Libo, Qian Liling. Clinical and Genetic Spectrum of Children with Primary Ciliary Dyskinesia in China. J Pediatr 2020, 225:157-65.10.Yuan Zhang#, Weicheng Chen#, Weijia Zeng, Zhouping Lu, Xiangyu Zhou. Biallelic loss of function NEK3 mutations deacetylate α-tubulin and downregulate NUP205 that predispose individuals to cilia-related abnormal cardiac left–right patterning. Cell Death and Disease 2020, 11:1005.11.Yangliu Song#, Weicheng Chen#, Zitong Huang#, Guixiang Tian, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Feizhen Wu, Maoxiang Qian, Xiaojing Ma, Wei Sheng, Guoying Huang. A Non-coding HES1 Variant Predisposes Children to Congenital Heart Disease in Chinese Population. Front Cell Dev Biol, 2021, 9: 631942.12. Hu Huifang#, Chen Weicheng#,*, Sheng Wei*, Huang Guoying*. High Familial Recurrence of Congenital Heart Defects in Laterality Defects Patients: An Evaluation of 184 Families. Pediatric Cardiology, 2021. 42(8): 1722-1729.13. Chen Weicheng#, Li Mengru#, Sheng Wei, Jia Bing*, Huang Guoying*. Congenital mitral valve defects in pediatric population: a narrative review of surgical repair. Pediatric Medicine, 2021.14. Chen Weicheng#, Zhang Yuan#, Shen Libing#, Zhu Jialiang, Cai Ke, Lu Zhouping, Zeng Weijia, Zhao Jianyuan*, Zhou Xiangyu*.(2022). Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease. Hum Genet. doi:10.1007/s00439-021-02426-51. 上海市出生缺陷防治重点实验室设立国家重点研发计划项目开放课题，2016YFC1000500，一个新的纤毛运动障碍/内脏异位候选基因DNAH2的识别与验证，2018/1-2019/12，10万，已结题，主持2. 上海市出生缺陷防治重点实验室开放课题，16DZKF1012，纤毛缺陷在房室间隔缺损发病机制中作用的研究，2016/10-2018/10，3万，已结题，主持3. 上海市卫生与计划委员会青年基金，20144Y0057，大动脉转位患者呼吸道纤毛运动障碍发生情况的研究，2015/01-2017/12，2万，已结题，主持4. 上海市出生缺陷防治重点实验室开放课题，14DZKF1007，纤毛运动及其相关致病基因在大动脉转位发病机制中作用的研究，2014/01-2016/12,5万，已结题，主持5. 上海市 “科技创新行动计划”自然科学基金项目，21ZR1409900，DNAH2调控纤毛运动在心脏左右不对称发育中的机制研究，2021/07-2024/06，20万，在研，主持

进修经历

工作经历

教育经历